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It also acts as a free radical scavenger [8,11,75,110,133,134,135] in vascular occlusion/occlusion-like failure studies, in particular [40,41,42,43,47,48,49,50,51,52,53,54,55,56], associated with its function as a stabilizer of cellular junction [11], leading to the significantly mitigated leaky gut syndrome [11]

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It is estimated that 1.5 million bone grafting procedures are performed annually in the USA and this figure is rapidly increasing due to population ageing [2, 7, 9–13]